A Cdk2 inhibitor
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CVT-313

Item No. 21044

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2'-[[6-[[(4-methoxyphenyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis-ethanol
CAS Number
199986-75-9
Synonyms
  • Cdk2 Inhibitor III
  • Cyclin-dependent kinase 2 Inhibitor III
Molecular Formula
C20H28N6O3
Formula Weight
400.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS(pH 7.2) (1:4): 0.2 mg/mlEthanol: 15 mg/ml
λmax
236, 293 nm
SMILES
OCCN(CCO)C1=NC(N(C(C)C)C=N2)=C2C(NCC3=CC=C(OC)C=C3)=N1
InChi Code
InChI=1S/C20H28N6O3/c1-14(2)26-13-22-17-18(21-12-15-4-6-16(29-3)7-5-15)23-20(24-19(17)26)25(8-10-27)9-11-28/h4-7,13-14,27-28H,8-12H2,1-3H3,(H,21,23,24)
InChi Key
NQVIIUBWMBHLOZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    CVT-313 is a competitive inhibitor of cyclin-dependent kinase 2 (Cdk2; IC50 = 0.5 µM in vitro).1 It displays 8.5- and 430-fold selectivity for Cdk2 over Cdk1 and Cdk4, respectively, and has no effect on other unrelated ATP-dependent serine/threonine kinases.1 CVT-313 induces cell cycle arrest at the G1/S boundary.1 CVT-313 is often used as a selective Cdk2 inhibitor, although at some concentrations and in some cells it may also inhibit Cdk1.1,2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brooks, E.E., Gray, N.S., Joly, A.H., et al. CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation. The Journal of Biological Chemisty 272(46), 29207-29211 (1997).

    2. Bhattacharjee, R.N., Banks, G.C., Trotter, K.W., et al. Histone H1 phosphorylation by Cdk2 selectively modulates mouse mammary tumor virus transcription through chromatin remodeling. Mol. Cell. Biol. 21(16), 5417-5454 (2001).

    3. Dong, P.P., Maddali, M.V., Srimani, J.K., et al. Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control. Nat. Commun. 5, 4750 (2014).

    4. Senderowicz, A.M., and Sausville, E.A. Preclinical and clinical development of cyclin-dependent kinase modulators. J. Natl. Cancer Inst. 92(5), 376-387 (2000).