An irreversible EGFR kinase inhibitor
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PD 168393

Item No. 21059

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-propenamide
CAS Number
194423-15-9
Molecular Formula
C17H13BrN4O
Formula Weight
369.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
λmax
243, 317, 347 nm
SMILES
BrC1=CC(NC2=NC=NC3=C2C=C(NC(C=C)=O)C=C3)=CC=C1
InChi Code
InChI=1S/C17H13BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h2-10H,1H2,(H,21,23)(H,19,20,22)
InChi Key
HTUBKQUPEREOGA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $110

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    10 mg

    $203

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    25 mg

    $420

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    Product Description

    PD 168393 is a cell-permeable, irreversible inhibitor of EGFR kinase activity (IC50 = 0.70 nM).1 It is effective in vivo, suppressing the growth of human epidermoid carcinoma xenografts in mice.1 PD 168393 is used in cells and in vivo to irreversibly inhibit EGFR signaling.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fry, D.W., Kraker, A.J., McMichael, A., et al. A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science 265(5175), 1093-1095 (1994).

    2. Pulit-Penaloza, J.A., Sapkota, B., Esser, E.S., et al. Modulation of influenza vaccine immune responses using an epidermal growth factor receptor kinase inhibitor. Sci. Rep. 5, 12321 (2015).

    3. Sun, X., Liang, J., Yao, X., et al. The activation of EGFR promotes myocardial tumor necrosis factor-α production and cardiac failure in endotoxemia. Oncotarget 6(34), 35478-35495 (2015).

    4. Wang, S.H., Wang, S.C., Chen, P.C., et al. Induction of cyclooxygenase-2 gene by Candida albicans through EGFR, ERK, and p38 pathways in human urinary epithelium. Med. Mycol. Epub ahead of print, (2016).