An internal standard for HPLC
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Isomer(s)
40907N4-Methylcytidine
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3-Methylcytidine (methosulfate)

Item No. 21064

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-methyl-cytidine, mono(methyl sulfate) salt
CAS Number
21028-20-6
Molecular Formula
C10H15N3O5 • CH4SO4
Formula Weight
369.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(N(C)C(C=C1)=N)N1[C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2.O=S(O)(OC)=O
InChi Code
InChI=1S/C10H15N3O5.CH4O4S/c1-12-6(11)2-3-13(10(12)17)9-8(16)7(15)5(4-14)18-9;1-5-6(2,3)4/h2-3,5,7-9,11,14-16H,4H2,1H3;1H3,(H,2,3,4)/t5-,7-,8-,9-;/m1./s1
InChi Key
MGSZKGKDQZQWAQ-BKZSBQMKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    Cayman Chemical
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    Product Description

    3-Methylcytidine (methosulfate) is a cytidine derivative used as an internal standard for HPLC. 3-Methylcytidine is a common epigenetic modification in tRNA but its role in the cell has not been defined.1 3-Methylcytidine has been investigated as a potential biomarker for cancer and was significantly elevated in the urine of breast cancer patients.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. D'Silva, S., Haider, S.J., and Phizicky, E.M. A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop. RNA 17(6), 1100-1110 (2011).

    2. Hsu, W.Y., Chen, C.J., Huang, Y.C., et al. Urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in Taiwanese. PLoS One 8(12), 1-8 (2013).