A pyrimidine nucleoside and derivative of cytidine
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N4-Methylcytidine

Item No. 40907

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-cytidine
CAS Number
10578-79-7
Synonyms
  • m4C
  • NSC 518744
Molecular Formula
C10H15N3O5
Formula Weight
257.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Slightly soluble: 0.1-1 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
CNC1=NC(N(C=C1)[C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)=O
InChi Code
InChI=1S/C10H15N3O5/c1-11-6-2-3-13(10(17)12-6)9-8(16)7(15)5(4-14)18-9/h2-3,5,7-9,14-16H,4H2,1H3,(H,11,12,17)/t5-,7-,8-,9-/m1/s1
InChi Key
LZCNWAXLJWBRJE-ZOQUXTDFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $50

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    50 mg

    $80

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    100 mg

    $119

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    250 mg

    $224

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    Product Description

    N4-Methylcytidine is a pyrimidine nucleoside and derivative of cytidine (Item No. 29602).1 It is found in mammalian mitochondrial rRNA where it stabilizes the structure of 12S rRNA and is essential for mitochondrial translation of oxidative phosphorylation-related proteins. N4-Methylcytidine maintains normal base pairing with the purine base guanine (Item No. 34248) in RNA oligomers.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Van Haute, L., Hendrick, A.G., D'Souza, A.R., et al. METTL15 introduces N4-methylcytidine into human mitochondrial 12S rRNA and is required for mitoribosome biogenesis. Nucleic Acids Res. 47(19), 10267-10281 (2019).

    2. Mao, S., Sekula, B., Ruszkowski, M., et al. Base pairing, structural and functional insights into N4-methylcytidine (m4C) and N4,N4-dimethylcytidine (m42C) modified RNA. Nucleic Acids Res. 48(18), 10087-10100 (2020).