A non-selective β-blocker
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Bucindolol

Item No. 21070

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2-hydroxy-3-[[2-(1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]-benzonitrile
CAS Number
71119-11-4
Synonyms
  • DL-Bucindolol
  • MJ13105-1
Molecular Formula
C22H25N3O2
Formula Weight
363.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 500 µg/ml
λmax
220, 283, 289 nm
SMILES
OC(CNC(C)(C)CC1=CNC2=C1C=CC=C2)COC3=CC=CC=C3C#N
InChi Code
InChI=1S/C22H25N3O2/c1-22(2,11-17-13-24-20-9-5-4-8-19(17)20)25-14-18(26)15-27-21-10-6-3-7-16(21)12-23/h3-10,13,18,24-26H,11,14-15H2,1-2H3
InChi Key
FBMYKMYQHCBIGU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $143

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    10 mg

    $259

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    Product Description

    Bucindolol is a third-generation, non-selective β-adrenergic receptor blocker that acts on both β1 and β2 receptors.1,2 Formulations containing β-blockers, such as bucindolol, are used in managing chronic heart failure.3 Bucindolol is also a weak α1-adrenoceptor antagonist, which may be linked to a mild vasodilator benefit.1,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bristow, M.R., Roden, R.I., Lowes, B.D., et al. The role of third-generation beta-blocking agents in chronic heart failure. Clin. Cardiol. 21(12 Suppl 1), I3-I13 (1998).

    2. Maack, C., Cremers, B., Flesch, M., et al. Different intrinsic activities of bucindolol, carvedilol and metoprolol in human failing myocardium. Br. J. Pharmacol. 130(5), 1131-1139 (2000).

    3. Smart, N.A., Kwok, N., Holland, D.J., et al. Bucindolol: A pharmacogenomic perspective on its use in chronic heart failure. Clin. Med. Insights Cardiol. 5, 55-66 (2011).