A tyrosinase inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Deoxyarbutin

Item No. 21077

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(tetrahydro-2H-pyran-2-yl)oxy]-phenol
CAS Number
53936-56-4
Molecular Formula
C11H14O3
Formula Weight
194.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 25 mg/mlEthanol:PBS (pH 7.2) (1:20): 0.04 mg/ml
λmax
225, 289 nm
SMILES
OC1=CC=C(OC2OCCCC2)C=C1
InChi Code
InChI=1S/C11H14O3/c12-9-4-6-10(7-5-9)14-11-3-1-2-8-13-11/h4-7,11-12H,1-3,8H2
InChi Key
GFBCWCDNXDKFRH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 g

    $54

    Add

    50 g

    $238

    Add

    100 g

    $290

    Add

    250 g

    $653

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Deoxyarbutin is a tyrosinase inhibitor (IC50 = 17.5 μM for mushroom tyrosinase).1 It reduces melanin content in isolated dark human melanocytes when used at a concentration of 1.56 μM.2 Topical administration of deoxyarbutin (5%) induces skin lightening in human skin mouse xenograft models. Deoxyarbutin also inhibits proliferation of B16/F10 murine melanoma cells (EC50 = 39.56 μM).3 It induces apoptosis and halts the cell cycle at the S phase in B16/F10 cells when used at a concentration of 50 μM. Deoxyarbutin (50 mg/kg) reduces tumor growth in a B16/F10 murine melanoma model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chawla, S., deLong, M.A., Visscher, M.O., et al. Mechanism of tyrosinase inhibition by deoxyArbutin and its second-generation derivatives. Br. J. Dermatol. 159(6), 1267-1274 (2008).

    2. Hamed, S.H., Sriwiriyanont, P., deLong, M.A., et al. Comparative efficacy and safety of deoxyarbutin, a new tyrosinase-inhibiting agent. J. Cosmet. Sci. 57(4), 291-308 (2006).

    3. Ma, L., Xu, Y., Wei, Z., et al. Deoxyarbutin displays antitumour activity against melanoma in vitro and in vivo through a p38-mediated mitochondria associated apoptotic pathway. Sci. Rep. 7(1), 7197 (2017).