A tyrosinase inhibitor
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Deoxyarbutin

Item No. 21077

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(tetrahydro-2H-pyran-2-yl)oxy]-phenol
CAS Number
53936-56-4
Molecular Formula
C11H14O3
Formula Weight
194.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 25 mg/mlEthanol:PBS (pH 7.2) (1:20): 0.04 mg/ml
λmax
225, 289 nm
SMILES
OC1=CC=C(OC2OCCCC2)C=C1
InChi Code
InChI=1S/C11H14O3/c12-9-4-6-10(7-5-9)14-11-3-1-2-8-13-11/h4-7,11-12H,1-3,8H2
InChi Key
GFBCWCDNXDKFRH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

    $54

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    250 g

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    Cayman Chemical
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    Product Description

    Deoxyarbutin is a tyrosinase inhibitor (IC50 = 17.5 μM for mushroom tyrosinase).1 It reduces melanin content in isolated dark human melanocytes when used at a concentration of 1.56 μM.2 Topical administration of deoxyarbutin (5%) induces skin lightening in human skin mouse xenograft models. Deoxyarbutin also inhibits proliferation of B16/F10 murine melanoma cells (EC50 = 39.56 μM).3 It induces apoptosis and halts the cell cycle at the S phase in B16/F10 cells when used at a concentration of 50 μM. Deoxyarbutin (50 mg/kg) reduces tumor growth in a B16/F10 murine melanoma model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chawla, S., deLong, M.A., Visscher, M.O., et al. Mechanism of tyrosinase inhibition by deoxyArbutin and its second-generation derivatives. Br. J. Dermatol. 159(6), 1267-1274 (2008).

    2. Hamed, S.H., Sriwiriyanont, P., deLong, M.A., et al. Comparative efficacy and safety of deoxyarbutin, a new tyrosinase-inhibiting agent. J. Cosmet. Sci. 57(4), 291-308 (2006).

    3. Ma, L., Xu, Y., Wei, Z., et al. Deoxyarbutin displays antitumour activity against melanoma in vitro and in vivo through a p38-mediated mitochondria associated apoptotic pathway. Sci. Rep. 7(1), 7197 (2017).