An adenine nucleotide containing two phosphate groups
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Alternative(s)
16778Adenosine 5'-diphosphate
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Adenosine 5'-diphosphate (potassium salt hydrate)

Item No. 21121

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
adenosine 5'-(trihydrogen diphosphate), monopotassium salt, hydrate
Synonyms
  • Adenosine Pyrophosphate
  • ADP
  • 5'-ADP
Molecular Formula
C10H15N5O10P2 • K [XH2O]
Formula Weight
466.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
257 nm
SMILES
O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(O)(O)=O)(O)=O)[C@H]1O.[K].O
InChi Code
InChI=1S/C10H15N5O10P2.K.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20);;1H2/t4-,6-,7-,10-;;/m1../s1
InChi Key
WKYJXLSNACHKHX-IDIVVRGQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 g

    $69

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    5 g

    $183

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    10 g

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    Product Description

    Adenosine 5'-diphosphate (ADP) is an adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5’ position. It is produced by dephosphorylation of adenosine 5’-triphosphate (ATP; Item No. 14498) by ATPases and can be converted back to ATP by ATP synthases. ADP can also be metabolized to adenosine 5’-monophosphate (AMP; Item No. 21094) and 2’-deoxyadenosine 5’-diphosphate (dADP). ADP can modulate several receptors, activating certain purinergic receptors (EC50 = 24 nM for P2Y1) and inhibiting others (IC50 = 67 nM for P2X2/3), inhibiting rat ecto-5’nucleotidase (Ki = 0.91 nM), and regulating the phosphorylation status of AMP-activated protein kinase (AMPK).1,2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Azran, S., Förster, D., Danino, O., et al. Highly efficient biocompatible neuroprotectants with dual activity as antioxidants and P2Y receptor agonists. J. Med. Chem. 56(12), 4938-4952 (2013).

    2. Baqi, Y., Lee, S.-Y., Iqbal, J., et al. Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold. J. Med. Chem. 53(5), 2076-2086 (2010).

    3. Jarvis, M.F., Bianchi, B., Uchic, J.T., et al. [3H]A-317491, a novel high-affinity non-nucleotide antagonist that specifically labels human P2X2/3 and P2X3 receptors. J. Pharmacol. Exp. Ther. 310(1), 407-416 (2004).

    4. Ruderman, N.B., Carling, D., Prentki, M., et al. AMPK, insulin resistance, and the metabolic syndrome. J. Clin. Invest. 123(7), 2764-2772 (2013).