A natural mycotoxin
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Isomer(s)
28589Dendryol D
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(-)-Altenuene

Item No. 21130

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2R,3R,4aR,4a-tetrahydro-2,3,7-trihydroxy-9-methoxy-4a-methyl-6H-dibenzo[b,d]pyran-6-one
CAS Number
889101-41-1
Molecular Formula
C15H16O6
Formula Weight
292.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetone: 10mg/ml
SMILES
O=C1C2=C(O)C=C(OC)C=C2C3=C[C@@H](O)[C@H](O)C[C@@]3(C)O1
InChi Code
InChI=1S/C15H16O6/c1-15-6-12(18)10(16)5-9(15)8-3-7(20-2)4-11(17)13(8)14(19)21-15/h3-5,10,12,16-18H,6H2,1-2H3/t10-,12-,15-/m1/s1
InChi Key
MMHTXEATDNFMMY-IXPVHAAZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $902

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    Product Description

    (-)-Altenuene is a natural mycotoxin that was first isolated from A. tenuis. It has antioxidant activity and inhibits cholinesterases.1 Unlike tenuazonic acid (Item No. 11443), (-)-altenuene does not display toxicity as assessed by the chicken embryo assay.2 (-)-Altenuene does not display significant topoisomerase inhibitory activity, unlike alternariol (Item No. 11306).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bhagat, J., Kaur, A., Kaur, R., et al. Cholinesterase inhibitor (Altenuene) from an endophytic fungus Alternaria alternata: Optimization, purification and characterization. J. Appl. Microbiol. 121(4), 1015-1025 (2016).

    2. Griffin, G.F., and Chu, F.S. Toxicity of the Alternaria metabolites alternariol, alternariol methyl ether, altenuene, and tenuazonic acid in the chicken embryo assay. Appl. Environ. Microbiol. 46(6), 1420-1422 (1983).

    3. Fehr, M., Pahlke, G., Fritz, J.E., et al. Alternariol acts as a topoisomerase poison, preferentially affecting the IIα isoform. Mol. Nutr. Food Res. 53(4), 441-451 (2008).