A cell-permeable inhibitor of CK2
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DMAT

Item No. 21182

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,5,6,7-tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amine
CAS Number
749234-11-5
Synonyms
  • Casein Kinase II Inhibitor II
  • 2-Dimethylamino-4,5,6,7-tetrabromobenzimidazole
Molecular Formula
C9H7Br4N3
Formula Weight
476.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:4): 0.20 mg/mlDMSO: 20 mg/ml
λmax
239, 271, 315 nm
SMILES
BrC1=C2C(NC(N(C)C)=N2)=C(Br)C(Br)=C1Br
InChi Code
InChI=1S/C9H7Br4N3/c1-16(2)9-14-7-5(12)3(10)4(11)6(13)8(7)15-9/h1-2H3,(H,14,15)
InChi Key
SLPJGDQJLTYWCI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $178

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    10 mg

    $312

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    25 mg

    $680

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    Product Description

    DMAT is a cell-permeable inhibitor of casein kinase 2 (CK2; IC50 = 0.13 µM).1 It also inhibits Pim-1, Pim-3, HIPK2, and HIPK3 (IC50s = 0.15, 0.097, 0.37, and 0.59 µM, respectively).1 DMAT blocks cell growth and induces cell death in cancer cells, both in culture and in mouse xenografts.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pagano, M.A., Bain, J., Kazimierczuk, Z., et al. The selectivity of inhibitors of protein kinase CK2: An update. Biochem. J. 415(3), 353-365 (2008).

    2. Lawnicka, H., Kowalewicz-Kulbat, M., Sicinska, P., et al. Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro. Cell Tissue Res. 340(2), 371-379 (2010).

    3. Sass, G., Klinger, N., Surma, H., et al. Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT. Int. J. Oncol. 39(2), 433-442 (2011).

    4. Yde, C.W., Frogne, T., Lykkesfeldt, A.E., et al. Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT. Cancer Lett. 256(2), 229-237 (2007).