A competitive antagonist of GCGR
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Glucagon Receptor Antagonist I

Item No. 21223

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-cyano-6-(1,1-dimethylpropyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]-2-ethyl-butanamide
CAS Number
438618-32-7
Synonyms
  • GCGR Antagonist I
Molecular Formula
C20H30N2OS
Formula Weight
346.5
Purity
≥99%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
216, 252, 260, 304 nm
SMILES
O=C(C(CC)CC)NC(S1)=C(C#N)C2=C1CC(C(C)(C)CC)CC2
InChi Code
InChI=1S/C20H30N2OS/c1-6-13(7-2)18(23)22-19-16(12-21)15-10-9-14(11-17(15)24-19)20(4,5)8-3/h13-14H,6-11H2,1-5H3,(H,22,23)
InChi Key
SWIBDWBSJSJQHL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    500 µg

    $82

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    1 mg

    $146

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    5 mg

    $524

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    Product Description

    Glucagon receptor antagonist I is a competitive antagonist of the glucagon receptor (GCGR; IC50 = 181 nM).1 It blocks glucagon-induced glycogenolysis in primary human hepatocytes and isolated liver.1 Glucagon receptor antagonist I, at 50 mg/kg, reduces the increase in glucose levels observed after intraperitoneal administration of glucagon in humanized mice.1 Glucagon receptor antagonist inactive control (Item No. 21188) does not prevent glucagon-mediated actions.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Qureshi, S.A., Candelore, M.R., Xie, D., et al. A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects. Diabetes 53(12), 3267-3273 (2004).