An ATP sulfurylase and APS Kinase inhibitor
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Adenosine 5'-phosphosulfate (sodium salt)

Item No. 21226

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5'-adenylic acid, sulfuric anhydride, disodium salt
CAS Number
102029-95-8
Synonyms
  • APS
Molecular Formula
C10H14N5O10PS • 2Na
Formula Weight
473.3
Purity
≥95%
Formulation (Request formulation change)
A 10 mM aqueous solution
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
260 nm
SMILES
O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OS(O)(=O)=O)(O)=O)[C@H]1O.[Na].[Na]
InChi Code
InChI=1S/C10H14N5O10PS.2Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22);;/t4-,6-,7-,10-;;/m1../s1
InChi Key
AVYOIJBTXNOSSY-IDIVVRGQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Adenosine 5’-phosphosulfate is an ATP and sulfate competitive inhibitor of ATP sulfurylase in humans, S. cerevisiae, and P. chrysogenum (Ki = 18, 2500, and 1500 nM, respectively).1,2 Adenosine 5'-phosphosulfate also inhibits human adenosine 5'-phosphosulfate kinase (Ki = 47.5 μM) to prevent sulfation.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Farley, J.R., Cryns, D.F., Yang, Y.H.J., et al. Adenosine triphosphate sulfurylase from Penicillium chrysogenum. Steady state kinetics of the forward and reverse reactions. The Journal of Biological Chemisty 251(14), 4389-4397 (1976).

    2. Landson, E.B., Fisher, A.J., and Segel, I.H. Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): Kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains. Biochemistry 43(14), 4656-4365 (2004).

    3. Mueller, J.W., and Shafqat, N. Adenosine-5'-phosphosulfate ‒ a multifaceted modulator of bifunctional 3'-phospho-adenosine-5'-phosphosulfate synthases and related enzymes. FEBS J. 280(13), 3050-3057 (2013).