An inhibitor of p38α and p38β MAP kinases
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p38 MAPK Inhibitor VIII

Item No. 21229

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[4-[(2-amino-4-bromophenyl)amino]-2-chlorophenyl](2-methylphenyl)-methanone
CAS Number
321351-00-2
Synonyms
  • EO 1428
  • p38 MAP Kinase Inhibitor VIII
  • p38 Mitogen-activated Protein Kinase Inhibitor VIII
Molecular Formula
C20H16BrClN2O
Formula Weight
415.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 50 mM
λmax
241, 339 nm
SMILES
BrC1=CC(N)=C(NC2=CC=C(C(C3=CC=CC=C3C)=O)C(Cl)=C2)C=C1
InChi Code
InChI=1S/C20H16BrClN2O/c1-12-4-2-3-5-15(12)20(25)16-8-7-14(11-17(16)22)24-19-9-6-13(21)10-18(19)23/h2-11,24H,23H2,1H3
InChi Key
HDCLCHNAEZNGNV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $49

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    5 mg

    $130

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    10 mg

    $236

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    Product Description

    p38 MAP kinase inhibitor VIII is an inhibitor of p38α (IC50 = 39 nM) and p38β MAP kinases with 82 and 93% inhibition, respectively, in a kinase assay when used at a concentration of 1 µM.1 It is selective for p38α and 38β, lacking activity at p38γ, p38δ, ERK1/2, and JNK1 at a concentration of 1 µM. p38 MAP kinase inhibitor VIII inhibits IL-1β, TNF-α, IL-6, IL-8, and IL-10, but not IFN-γ release from human peripheral blood mononuclear cells (PBMCs; IC50s = 30, 5, 17, 4, 10, and >1,000 nM, respectively). It also decreases ear swelling in mouse models of allergic and chronic irritative contact dermatitis when administered topically at a dose of 0.5 mg/ear.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ottosen, E.R., Sørensen, M.D., Björkling, F., et al. Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity. J. Med. Chem. 46(26), 5651-5662 (2003).