An agonist of P2Y receptors
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2-Methylthioadenosine diphosphate (sodium salt)

Item No. 21230

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(methylthio)-adenosine 5'-(trihydrogen diphosphate), trisodium salt
CAS Number
475193-31-8
Synonyms
  • 2-MeSADP
  • 2-methylthio ADP
Molecular Formula
C11H14N5O10P2S • 3Na
Formula Weight
539.2
Purity
≥98%
Formulation
A 10 mM solution in water
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/mlWater: Slightly soluble: 0.1-1 mg/mLWater: soluble
λmax
236, 275 nm
SMILES
O[C@H]1[C@H](N2C=NC3=C2N=C(SC)N=C3N)O[C@H](COP(OP([O-])([O-])=O)([O-])=O)[C@H]1O.[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C11H17N5O10P2S.3Na/c1-29-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(25-10)2-24-28(22,23)26-27(19,20)21;;;/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,23)(H2,12,14,15)(H2,19,20,21);;;/q;3*+1/p-3/t4-,6-,7-,10-;;;/m1.../s1
InChi Key
DYNGCIHMNWOBSU-MSQVLRTGSA-K
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $279

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    10 mg

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    Product Description

    2-Methylthioadenosine diphosphate (2-MeSADP) is an agonist of purinergic P2Y receptors with EC50s of 5.13 and 0.89 nM for human recombinant P2Y1 and P2Y12 receptors, respectively.1 It also acts as an agonist at rat P2Y1 and P2Y12 and mouse P2Y13 receptors (EC50s = 0.58, 0.89, and 6.2 nM, respectively).1,2 It induces platelet aggregation and inhibits cyclic AMP accumulation in platelet-rich plasma stimulated by prostaglandin E1 (PGE1; Item No. 13010) more potently than ADP (Item Nos. 21121 | 16778).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sak, K., and Webb, T.E. A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Arch. Biochem. Biophys. 397(1), 131-136 (2002).

    2. Zhang, F.L., Luo, L., Gustafson, E., et al. P2Y13: Identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse. J. Pharmacol. Exp. Ther. 301(2), 705-713 (2002).

    3. Macfarlane, D.E., Srovastava, P.C., and Mills, D.C. 2-Methylthioadenosine[β-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. J. Clin. Invest. 71(3), 420-428 (1983).