NCH-51

NCH-51 is an inhibitor of histone deacetylases (HDACs) with IC₅₀ values of 48, 32, and 41 nM for HDAC1, 4, and 6, respectively.¹ It increases acetylation of histone H4 and α-tubulin in HCT116 cells when used at concentrations ranging from 1 to 25 µM and inhibits the growth of a variety of cancer cell lines (EC₅₀s = 1.1-9.1 µM).^2,3 NCH-51 (0.4-1.6 µM) also induces HIV-1 viral replication in OM10.1 and ACH-2 cells latently infected with HIV-1 when used alone and, to a greater effect, when used in the presence of TNF-α, with cytotoxic concentration (CC₅₀) values of approximately 2 µM for both cell lines.¹

WARNING This product is not for human or veterinary use.

1. Victoriano, A.F.B., Imai, K., Togami, H., et al. Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expression. FEBS Lett. 585(7), 1103-1111 (2011).

2. Suzuki, T., Kouketsu, A., Itoh, Y., et al. Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate. J. Med. Chem. 49(16), 4809-4812 (2006).

3. Suzuki, T., Nagano, Y., Kouketsu, A., et al. Novel inhibitors of human histone deacetylases: Design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J. Med. Chem. 48(4), 1019-1032 (2005).