A potent D3 receptor agonist
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(+)-PD 128907 (hydrochloride)

Item No. 21235

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4,4aR,10bR-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol, monohydrochloride
CAS Number
300576-59-4
Molecular Formula
C14H19NO3 • HCl
Formula Weight
285.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 15 mg/mlEthanol: slightlyPBS (pH 7.2): 0.5 mg/ml
λmax
228, 297 nm
SMILES
OC1=CC=C(OC[C@]2([H])[C@]3([H])OCCN2CCC)C3=C1.Cl
InChi Code
InChI=1S/C14H19NO3.ClH/c1-2-5-15-6-7-17-14-11-8-10(16)3-4-13(11)18-9-12(14)15;/h3-4,8,12,14,16H,2,5-7,9H2,1H3;1H/t12-,14-;/m1./s1
InChi Key
DCFXOTRONMKUJB-QMDUSEKHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    (+)-PD 128907 is a potent agonist of the dopamine 3 (D3) receptor (Ki = 1 nM).1,2 It shows selectivity for D3 over D2 and D4 receptors (Kis = 1.2 and 7 µM, respectively).1 Low doses of (+)-PD 128907 (13 µg/kg, s.c.) reduce spontaneous locomotor activity in rats.3 It blocks stereotypy induced by the NMDA receptor antagonist (+)-MK-801 (Item No. 10009019) in mice.4 (+)-PD 128907 is used in animal models to study the role of the D3 receptor in nervous system disorders, such as schizophrenia, Parkinson’s disease, and depression.5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Akunne, H.C., Towers, P., Ellis, G.J., et al. Characterization of binding of [3H]PD 128907, a selective dopamine D3 receptor agonist ligand, to CHO-K1 cells. Life Sci. 57(15), 1401-1410 (1995).

    2. Pugsley, T.A., Davis, M.D., Akunne, H.C., et al. Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907. J. Pharmacol. Exp. Ther. 275(3), 1355-1366 (1995).

    3. Bristow, L.J., Cook, G.P., Gay, J.C., et al. The behavioural and neurochemical profile of the putative dopamine D3 receptor agonist, (+)-PD 128907, in the rat. Neuropharmacology 35(3), 285-294 (1996).

    4. Witkin, J., Gasior, M., Acri, J., et al. Atypical antipsychotic-like effects of the dopamine D3 receptor agonist, (+)-PD 128,907. Eur. J. Pharmacol. 347(2-3), R1-R3 (1998).

    5. Carcinella, S., Drui, G., Boulet, S., et al. Implication of dopamine D3 receptor activation in the reversion of Parkinson’s disease-related motivational deficits. Transl. Psychiatry 4(6), e401 (2014).

    6. Gil-Mast, S., Kortagere, S., Kota, K., et al. An amino acid residue in the second extracellular loop determines the agonist-dependent tolerance property of the human D3 dopamine receptor. ACS Chem Neurosci. 4(6), 940-951 (2013).