An expectorant
Related Products
Analytical Standard(s)
32998Guaifenesin
Labeled Version(s)
33368Guaifenesin-d3
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Product Categories

Product Type

Biochemicals

Research Area

Immunology & Inflammation

Guaifenesin

Item No. 21250

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(2-methoxyphenoxy)-1,2-propanediol
CAS Number
93-14-1
Synonyms
  • MY-301
  • NSC 62112
  • SL 90
  • XL90
Molecular Formula
C10H14O4
Formula Weight
198.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 15 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
226, 274 nm
SMILES
COC1=C(OCC(O)CO)C=CC=C1
InChi Code
InChI=1S/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3
InChi Key
HSRJKNPTNIJEKV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    25 g

    $22

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    50 g

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    100 g

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    250 g

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    Product Description

    Guaifenesin is an expectorant.1 It inhibits production of mucin 5AC (MUC5AC), reduces mucus viscosity and elasticity, and increases the mucociliary transport rate of endogenous particles in primary human tracheobronchial epithelial cells in a concentration-dependent manner.2 Guaifenesin (50 mg/kg, p.o.) increases phenol red secretion, a marker of expectorant activity, in rats.3 Formulations containing guaifenesin have been used as expectorants in the treatment of the common cold and chronic bronchitis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Seagrave, J., Albrecht, H.H., Hill, D.B., et al. Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cells. Respir. Res. 13(1), 98 (2012).

    2. Seagrave, J., Albrecht, H., Park, Y.S., et al. Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells. Exp. Lung Res. 37(10), 606-614 (2011).

    3. Kagan, L., Lavy, E., and Hoffman, A. Effect of mode of administration on guaifenesin pharmacokinetics and expectorant action in the rat model. Pulm. Pharmacol. Ther. 22(3), 260-265 (2009).