An internal standard for the quantification of guaifenesin
Related Products
Unlabeled Version(s)
21250Guaifenesin
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Guaifenesin-d3

Item No. 33368

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(2-(methoxy-d3)phenoxy)propane-1,2-diol
CAS Number
1189924-85-3
Synonyms
  • MY-301-d3
  • SL 90-d3
  • XL90-d3
Molecular Formula
C10H11D3O4
Formula Weight
201.2
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
OCC(O)COC1=C(C=CC=C1)OC([2H])([2H])[2H]
InChi Code
InChI=1S/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3/i1D3
InChi Key
HSRJKNPTNIJEKV-FIBGUPNXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $69

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    1 mg

    $127

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    5 mg

    $393

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    Product Description

    Guaifenesin-d3 is intended for use as an internal standard for the quantification of guaifenesin (Item No. 21250) by GC- or LC-MS. Guaifenesin is an expectorant.1 It inhibits production of mucin 5AC (MUC5AC), reduces mucus viscosity and elasticity, and increases the mucociliary transport rate of endogenous particles in primary human tracheobronchial epithelial cells in a concentration-dependent manner.2 Guaifenesin (50 mg/kg, p.o.) increases phenol red secretion, a marker of expectorant activity, in rats.3 Formulations containing guaifenesin have been used as expectorants in the treatment of the common cold and chronic bronchitis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Seagrave, J., Albrecht, H.H., Hill, D.B., et al. Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cells. Respir. Res. 13(1), 98 (2012).

    2. Seagrave, J., Albrecht, H., Park, Y.S., et al. Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells. Exp. Lung Res. 37(10), 606-614 (2011).

    3. Kagan, L., Lavy, E., and Hoffman, A. Effect of mode of administration on guaifenesin pharmacokinetics and expectorant action in the rat model. Pulm. Pharmacol. Ther. 22(3), 260-265 (2009).