A corticosteroid
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Labeled Version(s)
33365Clobetasol Propionate-d5
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Clobetasol Propionate

Item No. 21251

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
21-chloro-9-fluoro-11β-hydroxy-16β-methyl-17-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione
CAS Number
25122-46-7
Synonyms
  • CCl-4725
  • CGP 9555
  • Clobetasol 17-Propionate
Molecular Formula
C25H32ClFO5
Formula Weight
467.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 1 mg/ml
λmax
239 nm
SMILES
O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@H](C)[C@@]4(C(CCl)=O)OC(CC)=O)=C1
InChi Code
InChI=1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1
InChi Key
CBGUOGMQLZIXBE-XGQKBEPLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $40

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    1 g

    $70

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    5 g

    $246

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    10 g

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    Product Description

    Clobetasol propionate is a corticosteroid.1 It binds to glucocorticoid receptors in a cell-free assay (IC50 = 3.17 nM) and inhibits proliferation of primary human skin fibroblasts when used at a concentration of 5 µg/ml.1,2 Topical administration of clobetasol propionate reduces croton oil-induced ear edema in mice.1 Formulations containing clobetasol propionate have been used in the treatment of inflammatory skin conditions.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ueno, H., Maruyama, A., Miyake, M., et al. Synthesis and evaluation of antiinflammatory activities of a series of corticosteroid 17 α-esters containing a functional group. J. Med. Chem. 34(8), 2468-2473 (1991).

    2. Ponec, M., de Haas, C., Bachra, B.N., et al. Effects of glucocorticosteroids on primary human skin fibroblasts. I. Inhibition of the proliferation of cultured primary human skin and mouse L929 fibroblasts. Arch. Dermatol. Res. 259(12), 117-123 (1977).