An internal standard for the quantification of clobetasol propionate
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Unlabeled Version(s)
21251Clobetasol Propionate
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Clobetasol Propionate-d5

Item No. 33365

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy-2,2,3,3,3-d5)-(11β,16β)-pregna-1,4-diene-3,20-dione
CAS Number
2280940-18-1
Synonyms
  • CCI-4725-d5
  • CGP 9555-d5
  • Clobetasol 17-propionate-d5
Molecular Formula
C25H27ClD5FO5
Formula Weight
472.0
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: soluble
SMILES
O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@H](C)[C@@]4(C(CCl)=O)OC(C([2H])([2H])C([2H])([2H])[2H])=O)=C1
InChi Code
InChI=1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1/i1D3,5D2
InChi Key
CBGUOGMQLZIXBE-BFHSNLKKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $267

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    5 mg

    $1,196

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    Product Description

    Clobetasol propionate-d5 is intended for use as an internal standard for the quantification of clobetasol propionate (Item No. 21251) by GC- or LC-MS. Clobetasol propionate is a corticosteroid.1 It binds to glucocorticoid receptors in a cell-free assay (IC50 = 3.17 nM) and inhibits proliferation of primary human skin fibroblasts when used at a concentration of 5 µg/ml.1,2 Topical administration of clobetasol propionate reduces croton oil-induced ear edema in mice.1 Formulations containing clobetasol propionate have been used in the treatment of inflammatory skin conditions.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ueno, H., Maruyama, A., Miyake, M., et al. Synthesis and evaluation of antiinflammatory activities of a series of corticosteroid 17 α-esters containing a functional group. J. Med. Chem. 34(8), 2468-2473 (1991).

    2. Ponec, M., de Haas, C., Bachra, B.N., et al. Effects of glucocorticosteroids on primary human skin fibroblasts. I. Inhibition of the proliferation of cultured primary human skin and mouse L929 fibroblasts. Arch. Dermatol. Res. 259(12), 117-123 (1977).