A histamine H1 receptor antagonist
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Labeled Version(s)
35767Chlorpheniramine-d6 (maleate)
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Chlorpheniramine (maleate)

Item No. 21253

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
γ-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine, 2Z-butenedioate
CAS Number
113-92-8
Synonyms
  • (±)-Chlorpheniramine
  • Chlorprophenpyridamine
Molecular Formula
C16H19ClN2 • C4H4O4
Formula Weight
390.9
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 10 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
262 nm
SMILES
ClC(C=C1)=CC=C1C(CCN(C)C)C2=CC=CC=N2.OC(/C=C\C(O)=O)=O
InChi Code
InChI=1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChi Key
DBAKFASWICGISY-BTJKTKAUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

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    50 g

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    Product Description

    Chlorpheniramine is a histamine H1 receptor antagonist with an IC75 value of 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum.1 It protects against intravenous histamine-induced death (PD50 = 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED100sec = 0.44 mg/kg) in guinea pigs. Chlorpheniramine (20 mg/kg, i.p.) prevents histamine-induced passive cutaneous anaphylaxis (PCA) in rabbits.2 It also reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma.3 Formulations containing chlorpheniramine have been used in the treatment of seasonal allergies.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lish, P.M., Robbins, S.I., and Peters, E.L. Specificity of antihistamine drugs and involvement of the adrenergic system in histamine deaths in the guinea pig. J. Pharmacol. Exp. Ther. 153(3), 538-543 (1966).

    2. Henson, P.M., and Cochrane, C.G. Immunological induction of increased vascular permeability. I. A rabbit passive cutaneous anaphylactic reaction requiring complement, platelets, and neutrophils. J. Exp. Med. 129(1), 153-165 (1969).

    3. Yamatake, Y., Sasagawa, S., Yanaura, S., et al. Involvement of histamine H1- and H2-receptors in induced asthmas in dogs. Jpn. J. Pharmacol. 27(6), 791-797 (1977).