A selective nociceptin receptor antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

JTC 801

Item No. 21254

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]-benzamide, monohydrochloride
CAS Number
244218-51-7
Molecular Formula
C26H25N3O2 • HCl
Formula Weight
448.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2)(1:5): 0.16 mg/mlEthanol: 20 mg/ml
λmax
223, 270, 311, 341 nm
SMILES
CC1=NC2=CC=C(NC(C3=C(COC4=CC=C(CC)C=C4)C=CC=C3)=O)C=C2C(N)=C1.Cl
InChi Code
InChI=1S/C26H25N3O2.ClH/c1-3-18-8-11-21(12-9-18)31-16-19-6-4-5-7-22(19)26(30)29-20-10-13-25-23(15-20)24(27)14-17(2)28-25;/h4-15H,3,16H2,1-2H3,(H2,27,28)(H,29,30);1H
InChi Key
NQLIYKXNAXKMBL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $63

    Add

    10 mg

    $118

    Add

    25 mg

    $274

    Add

    50 mg

    $481

    Add
    Product Description

    JTC 801 is an antagonist of the nociceptin receptor (ORL1; Ki = 44.5 nM; IC50 = 94 nM) that is >100-, >100-, and >3-fold more selective for ORL1 over the related δ-, κ-, and µ-opioid receptors, respectively.1 It demonstrates anti-nociceptive effects in acute pain models in mice upon oral administration at 1 mg/kg.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yamada, H., Nakamoto, H., Suzuki, Y., et al. Pharmacological profiles of a novel opioid receptor-like1 (ORL(1)) receptor antagonist, JTC-801. Br. J. Pharmacol. 135(2), 323-332 (2002).