A P-glycoprotein inhibitor
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MC70

Item No. 21330

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4'-[(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)methyl]-[1,1'-biphenyl]-4-ol
CAS Number
1031367-64-2
Molecular Formula
C24H25NO3
Formula Weight
375.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
281 nm
SMILES
COC1=C(OC)C=C(CN(CC2=CC=C(C3=CC=C(O)C=C3)C=C2)CC4)C4=C1
InChi Code
InChI=1S/C24H25NO3/c1-27-23-13-20-11-12-25(16-21(20)14-24(23)28-2)15-17-3-5-18(6-4-17)19-7-9-22(26)10-8-19/h3-10,13-14,26H,11-12,15-16H2,1-2H3
InChi Key
ATYXTVKHMLAWBZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $242

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    10 mg

    $387

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    25 mg

    $769

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    Cayman Chemical
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    Product Description

    MC70 is a P-glycoprotein (P-gp) inhibitor.1 It inhibits the efflux of [3H]vinblastine by ATP binding cassette subfamily B member 1 (ABCB1) in Caco-2 colon cancer cells (EC50 = 0.05 µM). MC70 also inhibits the efflux of rhodamine-123 (Item No. 16672) and calcein-AM (Item No. 14948) by breast cancer resistant protein (BCRP) and multidrug resistance-associated protein 1 (MRP1) in MDCK cells (EC50s = 73 and 9.3 µM, respectively). MC70 (2 or 20 µM) enhances growth inhibition of adriamycin and doxorubicin-resistant (ADR) MCF-7/ADR breast cancer cells when used in combination with doxorubicin (Item No. 15007), but does not alter the effectiveness of doxorubicin on growth inhibition in Caco-2 cells.2 It increases phosphorylation of p38 and JNK in Caco-2 cells and MCF-7/ADR cells when used at a concentration of 20 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Colabufo, N.A., Berardi, F., Perrone, M.G., et al. Multi-drug-resistance-reverting agents: 2-Aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors. ChemMedChem 4(2), 188-195 (2009).

    2. Azzariti, A., Quatrale, A.E., Porcelli, L., et al. MC70 potentiates doxorubicin efficacy in colon and breast cancer in vitro treatment. Eur. J. Pharmacol. 670(1), 74-84 (2011).