A serotonin receptor antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Metergoline

Item No. 21336

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[(8β)-1,6-dimethylergolin-8-yl]methyl]-carbamic acid, phenylmethyl ester
CAS Number
17692-51-2
Molecular Formula
C25H29N3O2
Formula Weight
403.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 25 mg/mlEthanol: 5 mg/ml
λmax
226, 289 nm
SMILES
CN1C2=CC=CC([C@@]3([H])C[C@@H](CNC(OCC4=CC=CC=C4)=O)CN(C)[C@]3([H])C5)=C2C5=C1
InChi Code
InChI=1S/C25H29N3O2/c1-27-14-18(13-26-25(29)30-16-17-7-4-3-5-8-17)11-21-20-9-6-10-22-24(20)19(12-23(21)27)15-28(22)2/h3-10,15,18,21,23H,11-14,16H2,1-2H3,(H,26,29)/t18-,21+,23+/m0/s1
InChi Key
WZHJKEUHNJHDLS-QTGUNEKASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    Product Description

    Metergoline is a serotonin (5-HT) receptor antagonist that is active at 5-HT1 (pKi = 7.8 for 5-HT1B), 5-HT2, (pKi = 8.64, 8.75, and 8.75 for 5-HT2A, 5-HT2B, and 5-HT2C respectively), and 5-HT7 receptor subtypes.1,2 It blocks 5-HT7 receptor-stimulated cAMP production (IC50 = 321 nM) in HEK293 cells.3 Metergoline has been widely used to study serotonin receptor function, but it also dose-dependently inhibits voltage-dependent sodium and potassium channels transfected into Xenopus oocytes.4,5 Formulations containing metergoline have been studied for the treatment of hormone dysfunction, seasonal affective disorder, and anxiety.4

    WARNING This product is not for human or veterinary use.