A potent and selective VEGFR2 inhibitor
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ZM 323881 (hydrochloride)

Item No. 21347

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]-phenol, monohydrochloride
CAS Number
193000-39-4
Molecular Formula
C22H18FN3O2 • HCl
Formula Weight
411.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
λmax
250, 321 nm
SMILES
FC1=CC(C)=C(O)C=C1NC2=NC=NC3=CC(OCC4=CC=CC=C4)=CC=C32.Cl
InChi Code
InChI=1S/C22H18FN3O2.ClH/c1-14-9-18(23)20(11-21(14)27)26-22-17-8-7-16(10-19(17)24-13-25-22)28-12-15-5-3-2-4-6-15;/h2-11,13,27H,12H2,1H3,(H,24,25,26);1H
InChi Key
AVRHWGLIYGJSOD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $236

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    25 mg

    $502

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    Product Description

    ZM 323881 is a potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2; IC50 = <2 nM), a receptor tyrosine kinase.1 It is selective for VEGFR2 over VEGFR1, PDGFRβ, FGFR1, EGFR, and ErbB2 at concentrations greater than 50 µM. It inhibits VEGF-A-stimulated cell proliferation of human umbilical vein endothelial cells (HUVECs; IC50 = 8 nM) but not basal proliferation or that stimulated by EGF or bFGF (IC50s = >5,000, 1,900, and 1,600 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Whittles, C.E., Pocock, T.M., Wedge, S.R., et al. ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity. Microcirculation 9(6), 513-522 (2002).