An RAR agonist and an active metabolite of tazarotene
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Pro-drug Form(s)
23559Tazarotene
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Tazarotenic Acid

Item No. 21367

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[2-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylic acid
CAS Number
118292-41-4
Synonyms
  • AGN 190299
Molecular Formula
C19H17NO2S
Formula Weight
323.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml
λmax
257, 347 nm
SMILES
OC(C1=CC=C(C#CC2=CC(C(C)(C)CCS3)=C3C=C2)N=C1)=O
InChi Code
InChI=1S/C19H17NO2S/c1-19(2)9-10-23-17-8-4-13(11-16(17)19)3-6-15-7-5-14(12-20-15)18(21)22/h4-5,7-8,11-12H,9-10H2,1-2H3,(H,21,22)
InChi Key
IQIBKLWBVJPOQO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    25 mg

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    50 mg

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    Product Description

    Tazarotenic acid is a retinoic acid receptor (RAR) agonist and an active metabolite of the retinoid prodrug tazarotene (Item No. 23559).1 It induces reporter gene expression in DK7-NR cells expressing human RARα, RARβ, or RARγ (EC50s = 11, 2.5, and 11 nM, respectively). Topical application of tazarotenic acid (0.1% w/w) reduces ear edema in a mouse model of epidermal inflammation induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aubert, J., Piwinica, D., Bertino, B., et al. Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor-γ agonist trifarotene. Br. J. Dermatol. 179(2), 442-456 (2018).