An α2C- and α1D-adrenoceptor antagonist and 5-HT1A partial agonist
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BMY 7378

Item No. 21369

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione, dihydrochloride
CAS Number
21102-95-4
Molecular Formula
C22H31N3O3 • 2HCl
Formula Weight
458.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 25 mg/mlEthanol: 0.2 mg/mlPBS (pH 7.2): 0.5 mg/ml
λmax
208, 240, 279 nm
SMILES
COC1=CC=CC=C1N2CCN(CCN3C(CC4(CCCC4)CC3=O)=O)CC2.Cl.Cl
InChi Code
InChI=1S/C22H31N3O3.2ClH/c1-28-19-7-3-2-6-18(19)24-13-10-23(11-14-24)12-15-25-20(26)16-22(17-21(25)27)8-4-5-9-22;;/h2-3,6-7H,4-5,8-17H2,1H3;2*1H
InChi Key
NIBOMXUDFLRHRV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $49

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    25 mg

    $107

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    50 mg

    $154

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    100 mg

    $283

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    Product Description

    BMY 7378 is an antagonist of the α2C-adrenoceptor and α1D-adrenoceptor with pKi values of 6.54 and 8.2, respectively, that has been used in functional systems to assess the contribution of these receptors in vascular smooth muscle contraction.1,2 It also acts as a partial agonist at the serotonin 5-HT1A receptor with a pKi value of 8.3.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Goetz, A.S., King, H.K., Ward, S.D., et al. BMY 7378 is a selective antagonist of the D subtype of alpha 1-adrenoceptors. Eur. J. Pharmacol. 272(2-3), R5-R6 (1995).

    2. Cleary, L., Murad, K., Bexis, S., et al. The alpha (1D)-adrenoceptor antagonist BMY 7378 is also an alpha (2C)-adrenoceptor antagonist. Auton. Autacoid Pharmacol. 25(4), 135-141 (2005).