A potent 5-HT2A receptor antagonist
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

MDL 11939

Item No. 21414

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-phenyl-1-(2-phenylethyl)-4-piperidinemethanol
CAS Number
107703-78-6
Molecular Formula
C20H25NO
Formula Weight
295.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 50mMEthanol: 50mM
SMILES
OC(C1CCN(CCC2=CC=CC=C2)CC1)C3=CC=CC=C3
InChi Code
InChI=1S/C20H25NO/c22-20(18-9-5-2-6-10-18)19-12-15-21(16-13-19)14-11-17-7-3-1-4-8-17/h1-10,19-20,22H,11-16H2
InChi Key
AXNGJCOYCMDPQG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $50

    Add

    5 mg

    $134

    Add
    Product Description

    MDL 11939 is a potent, orally bioavailable, and selective antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 6.06 nM for the human receptor).1 It is selective for the human 5-HT2A receptor over human 5-HT2B and 5-HT2C and rat 5-HT2B receptors (Kis = 3,020, 1,020, and 4,700 nM, respectively), as well as 5-HT1, 5-HT1A, α1- and α2-adrenergic, dopamine D2, muscarinic acetylcholine, histamine, and opiate receptors.1,2 MDL 11939 administered to rats prior to or following learned helplessness-induced stress prevents increases in acoustic startle response.3 MDL 11939 (10 mg/kg, i.v.) also has anti-arrhythmic activity in anesthetized dogs following myocardial infarction.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dudley, M.W., Wiech, N.L., Miller, F.P., et al. Pharmacological effects of MDL 11,939: A selective, centrally acting antagonist of 5-HT2 receptors. Drug Dev. Res. 13(1), 29-43 (1988).

    2. Wainscott, D.B., Lucaites, V.L., Kursar, J.D., et al. Pharmacologic characterization of the human 5-hydroxytryptamine2B receptor: Evidence for species differences. J. Pharmacol. Exp. Ther. 276(2), 720-727 (1996).

    3. Jiang, X., Zhang, Z.-j., Zhang, S., et al. 5-HT2A receptor antagonism by MDL 11,939 during inescapable stress prevents subsequent exaggeration of acoustic startle response and reduced body weight in rats. J. Psychopharmacol. 25(2), 289-297 (2011).

    4. Koerner, J.E., and Dage, R.C. Antiarrhythmic and electrophysiologic effects of MDL 11,939, a novel class III antiarrhythmic agent in anesthetized dogs. J. Cardiovasc. Pharmacol. 16(3), 383-393 (1990).