An inhibitor of Cdk1 and Cdk2
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NU 2058

Item No. 21415

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(cyclohexylmethoxy)-9H-purin-2-amine
CAS Number
161058-83-9
Synonyms
  • O6-(Cyclohexylmethyl)guanine
Molecular Formula
C12H17N5O
Formula Weight
247.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2) (1:7): 0.12 mg/mlEthanol: 1 mg/ml
λmax
241, 282 nm
SMILES
NC1=NC2=NC=NC2=C(N1)OCC3CCCCC3
InChi Code
InChI=1S/C12H17N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h7-8H,1-6H2,(H3,13,14,15,16,17)
InChi Key
MWGXGTJJAOZBNW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $70

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    10 mg

    $117

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    50 mg

    $369

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    100 mg

    $469

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    Product Description

    NU 2058 is an inhibitor of cyclin-dependent kinase 1 (Cdk1) and Cdk2 (IC50s = 7.0 and 17 µM, respectively).1,2 Increased Cdk activity is often associated with human tumors, and inhibitors of Cdks, including NU 2058, can arrest cell cycling in cancer cells in vitro.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hardcastle, I.R., Arris, C.E., Bentley, J., et al. N2-substituted O6-cyclohexylmethylguanine derivatives: Potent inhibitors of cyclin-dependent kinases 1 and 2. J. Med. Chem. 47(15), 3710-3722 (2004).

    2. Sayle, K.L., Bentley, J., Boyle, F.T., et al. Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2. Bioorg. Med. Chem. Lett. 13(18), 3079-3082 (2003).

    3. Johnson, N., Bentley, J., Wang, L.-Z., et al. Pre-clinical evaluation of cyclin-dependent kinase 2 and 1 inhibition in anti-estrogen-sensitive and resistant breast cancer cells. Br. J. Cancer 102(2), 342-350 (2010).

    4. Rigas, A.C., Robson, C.N., and Curtin, N.J. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer. Oncogene 26(55), 7611-7619 (2007).