A muscarinic receptor antagonist
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Clidinium (bromide)

Item No. 21428

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2.2.2]octane, monobromide
CAS Number
3485-62-9
Synonyms
  • Ro 2-3773
Molecular Formula
C22H26NO3 • Br
Formula Weight
432.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(C(C1=CC=CC=C1)(O)C2=CC=CC=C2)OC3C[N+]4(C)CCC3CC4.[Br-]
InChi Code
InChI=1S/C22H26NO3.BrH/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19;/h2-11,17,20,25H,12-16H2,1H3;1H/q+1;/p-1
InChi Key
GKEGFOKQMZHVOW-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $49

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    1 g

    $81

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    Product Description

    Clidinium is a gastrointestinal muscarinic receptor antagonist (Ki = 3 nM against [3H]quinuclidinyl benzilate binding in rat colonic enterocytes).1 Administration of clidinium, at a dose of 1 mg/kg, slows intestinal transit and induces constipation in mice.2 This clidinium-induced constipation induces serum hyperammonemia and decreases clonic, myoclonic, and tonic seizure thresholds in a murine pentylenetetrazole-induced epilepsy model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zimmerman, T.W., and Binder, H.J. Muscarinic receptors on rat isolated colonic epithelial cells. A correlation between inhibition of [3H]quinuclidinyl benzilate binding and alteration in ion transport. Gastroenterology 83(6), 1244-1251 (1982).

    2. Moezi, L., Pirsalami, F., and Inaloo, S. Constipation enhances the propensity to seizure in pentylenetetrazole-induced seizure models of mice. Epilepsy Behav. 44, 200-206 (2015).