AS-101

AS-101 is an immunomodulator.¹ It inhibits IL-10 secretion from and cell proliferation of IL-10-secreting human stomach adenocarcinoma and glioblastoma multiforme (GBM) cells when used at concentrations ranging from 0.5 to 2.5 µg/ml, an effect that can be blocked by the addition of recombinant IL-10. It reverses IL-10-induced increases in phosphorylated Stat3 and reduces the expression of Bcl-2 in B16 murine melanoma cells. AS-101 sensitizes GBM cells to paclitaxel (Item No. 10461), doxorubicin (Item No. 15007), and 5-fluorouracil (5-FU; Item No. 14416) in vitro and to paclitaxel in a GBM mouse xenograft model when administered at a dose of 0.5 mg/kg per day. AS-101 (1 mg/kg) also prevents infiltration of CD49d⁺ cells and decreases the expression of IL-6, TNF-α, IL-1β, and MCP-1 in the spinal cord, as well as delays onset and slows the progression of symptoms in a mouse model of experimental autoimmune encephalomyelitis (EAE).²

WARNING This product is not for human or veterinary use.

1. Sredni, B., Weil, M., Khomenok, G., et al. Ammonium trichloro(dioxoethylene-o,o')tellurate (AS101) sensitizes tumors to chemotherapy by inhibiting the tumor interleukin 10 autocrine loop. Cancer Res. 64(5), 1843-1852 (2004).

2. Lee, J.H., Halperin-Sheinfeld, M., Baatar, D., et al. Tellurium compound AS101 ameliorates experimental autoimmune encephalomyelitis by VLA-4 inhibition and suppression of monocyte and T cell infiltration into the CNS. Neuromolecular Med. 16(2), 292-307 (2014).