A prodrug form of FdUMP
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5-Fluorouracil

Item No. 14416

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-fluoro-2,4(1H,3H)-pyrimidinedione
CAS Number
51-21-8
Synonyms
  • 5-FU
  • NSC 19893
  • Ro 2-9757
  • U-8953
Molecular Formula
C4H3FN2O2
Formula Weight
130.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 60 mg/mlDMSO: 53 mg/mlEthanol: 0.8 mg/mlPBS (pH 7.2): 8 mg/ml
λmax
266 nm
SMILES
O=C1NC(NC=C1F)=O
InChi Code
InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
InChi Key
GHASVSINZRGABV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $54

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    10 g

    $103

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    25 g

    $175

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    50 g

    $324

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    Product Description

    5-Fluorouracil (5-FU) is a prodrug form of the thymidylate synthase inhibitor fluorodeoxyuridylate (FdUMP).1 It is also converted to the active metabolites FUTP and FdUTP, which induce RNA and DNA damage, respectively. In vivo, 5-FU (15 mg/kg) when administered in combination with docetaxel (Item No. 11637) reduces tumor growth in B88 and CAL 27 oral squamous cell carcinoma (OSCC) mouse xenograft models.2 Formulations containing 5-FU have been used in the treatment of colorectal, breast, gastric, and pancreatic cancers.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Longley, D.B., Harkin, D.P., and Johnston, P.G. 5-fluorouracil: Mechanisms of action and clinical strategies. Nat. Rev. Cancer 3(5), 330-338 (2003).

    2. Tamatani, T., Ferdous, T., Takamaru, N., et al. Antitumor efficacy of sequential treatment with docetaxel and 5-fluorouracil against human oral cancer cells. Int. J. Oncol. 41(3), 1148-1156 (2012).

    Product Citations

    Kremer, D.M., Nelson, B.S., Lin, L., et al. GOT1 inhibition primes pancreatic cancer for ferroptosis through the autophagic release of labile iron. bioRxiv (2020).