An antiviral nucleoside analog
Related Products
Enantiomer(s)
20519Thymidine
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Telbivudine

Item No. 21453

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(2-deoxy-β-L-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
CAS Number
3424-98-4
Synonyms
  • 2'-deoxy-L-Thymidine
  • L-Deoxythymidine
  • NV 02B
  • β-L-Thymidine
Molecular Formula
C10H14N2O5
Formula Weight
242.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
267 nm
SMILES
O=C(C(C)=CN1[C@H]2O[C@@H](CO)[C@H](O)C2)N([H])C1=O
InChi Code
InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m1/s1
InChi Key
IQFYYKKMVGJFEH-CSMHCCOUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $63

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    10 mg

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    25 mg

    $197

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    100 mg

    $722

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    Cayman Chemical
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    Product Description

    Telbivudine is a β-L-nucleoside analog of thymidine (Item No. 20519) that has antiviral activity.1,2 It is active against hepatitis B virus (HBV) in 2.2.15 cells (EC50 = 0.19 μM).2 Telbivudine is selective for HBV over HIV-1, herpes simplex virus-1 (HSV-1), HSV-2, and influenza A and B (EC50s = >100 μM). It reduces serum viral load in a woodchuck model of chronic HBV infection in a dose-dependent manner. Formulations containing telbivudine have been used in the treatment of chronic HBV infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Han, S.-H.B. Telbivudine: A new nucleoside analogue for the treatment of chronic hepatitis B. Expert Opin. Investig. Drugs 14(4), 511-519 (2005).

    2. Bryant, M.L., Bridges, E.G., Placidi, L., et al. Antiviral β-L-nucleosides specific for hepatitis B virus infection. Antimicrob. Agents Chemother. 45(1), 229-235 (2001).