A DPP-4 inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

MK-3102

Item No. 21454

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2,6-dihydro-2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine
CAS Number
1226781-44-7
Synonyms
  • Omarigliptin
Molecular Formula
C17H20F2N4O3S
Formula Weight
398.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 1 mg/ml
λmax
268 nm
SMILES
FC1=CC([C@@H]2[C@@H](N)C[C@@H](N3CC4=NN(S(=O)(C)=O)C=C4C3)CO2)=C(F)C=C1
InChi Code
InChI=1S/C17H20F2N4O3S/c1-27(24,25)23-7-10-6-22(8-16(10)21-23)12-5-15(20)17(26-9-12)13-4-11(18)2-3-14(13)19/h2-4,7,12,15,17H,5-6,8-9,20H2,1H3/t12-,15+,17-/m1/s1
InChi Key
MKMPWKUAHLTIBJ-ISTRZQFTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $63

    Add

    5 mg

    $242

    Add

    10 mg

    $435

    Add

    25 mg

    $974

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    MK-3102 is an inhibitor of dipeptidyl peptidase 4 (DPP-4; IC50 = 1.6 nM).1 It is selective for DPP-4 over several proteases, including DPP-7, DPP-8, DPP-9, and fibroblast activation protein (FAP; IC50s = >67 µM for all), as well as the ion channels delayed-rectifier potassium current (Ikr), L-type voltage-gated calcium channel 1.2 (Cav1.2), and voltage-gated sodium channel 1.5 (Nav1.5; IC50s = >30 µM for all) and a panel of 168 enzymes (IC50s = >10 µM for all). MK-3102 (0.3 mg/kg) reduces blood glucose levels by 51% in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Biftu, T., Sinha-Roy, R., Chen, P., et al. Omarigliptin (MK-3102): A novel long-acting DPP‑4 inhibitor for once-weekly treatment of Type 2 Diabetes. J. Med. Chem. 57(8), 3205-3212 (2014).