A selective D3 antagonist
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NGB 2904 (hydrochloride)

Item No. 21457

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide, monohydrochloride
CAS Number
189061-11-8
Molecular Formula
C28H29Cl2N3O • HCl
Formula Weight
530.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 25 mMEthanol: 5 mM
λmax
282, 306 nm
SMILES
ClC1=C(Cl)C(N2CCN(CCCCN([H])C(C3=CC(CC4=C5C=CC=C4)=C5C=C3)=O)CC2)=CC=C1.Cl
InChi Code
InChI=1S/C28H29Cl2N3O.ClH/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24;/h1-2,5-11,19H,3-4,12-18H2,(H,31,34);1H
InChi Key
PFIWYJNBKGCVFM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    Product Description

    NGB 2904 is an antagonist that is selective for the dopamine D3 receptor (Ki = 1.4 nM).1 It potently inhibits quinpirole-stimulated mitogenesis (IC50 = 6.8 nM).2 NGB 2904 attenuates cocaine- and stress-induced reinstatement of drug-seeking behavior in rats.3,4 It also increases spontaneous and amphetamine-stimulated locomotion in mice.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yuan, J., Chen, X., Brodbeck, R., et al. NGB 2904 and NGB 2849: Two highly selective dopamine D3 receptor antagonists. Bioorg. Med. Chem. Lett. 8(19), 2715-2718 (1998).

    2. Grundt, P., Carlson, E.E., Cao, J., et al. Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor. J. Med. Chem. 48(3), 839-848 (2005).

    3. Gilbert, J.G., Newman, A.H., Gardner, E.L., et al. Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: Role of dopamine D3 receptors. Synapse 57(1), 17-28 (2005).

    4. Xi, Z.-X., Newman, A.H., Gilbert, J.G., et al. The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine’s rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. Neuropsychopharmacology 31(7), 1393-1405 (2006).

    5. Pritchard, L.M., Newman, A.H., McNamara, R.K., et al. The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion. Pharmacol. Biochem. Behav. 86(4), 718-726 (2007).