An mGluR1b antagonist
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CPCCOEt

Item No. 21486

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7,7a-dihydro-7-(hydroxyimino)-benzo[b]cyclopropa[e]pyran-1a(1H)-carboxylic acid, ethyl ester
CAS Number
179067-99-3
Molecular Formula
C13H13NO4
Formula Weight
247.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mM
SMILES
CCOC(C1(C2)C2/C(C3=CC=CC=C3O1)=N\O)=O
InChi Code
InChI=1S/C13H13NO4/c1-2-17-12(15)13-7-9(13)11(14-16)8-5-3-4-6-10(8)18-13/h3-6,9,16H,2,7H2,1H3/b14-11-
InChi Key
FXCTZFMSAHZQTR-KAMYIIQDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $42

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    5 mg

    $115

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    10 mg

    $161

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    Product Description

    CPCCOEt is a low affinity, selective, non-competitive antagonist of the metabotropic glutamate receptor subtype mGluR1b. It has been shown to inhibit glutamate-induced increases in intracellular calcium at human mGluR1b with an IC50 value of 6.5 µM while having no agonist or antagonist activity at mGluR2, -4a, -5a, -7b, and -8a at concentrations up to 100 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Litschig, S., Gasparini, F., Rueegg, D., et al. CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. Mol. Pharmacol. 55(3), 453-461 (1999).