An allosteric Lyn kinase activator
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

MLR-1023

Item No. 21496

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(3-methylphenoxy)-2(1H)-pyrimidinone
CAS Number
41964-07-2
Synonyms
  • CP 26,154
  • NSC 314335
Molecular Formula
C11H10N2O2
Formula Weight
202.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 1 mg/ml
λmax
225, 276, 330 nm
SMILES
CC1=CC=CC(OC2=CN([H])C(N=C2)=O)=C1
InChi Code
InChI=1S/C11H10N2O2/c1-8-3-2-4-9(5-8)15-10-6-12-11(14)13-7-10/h2-7H,1H3,(H,12,13,14)
InChi Key
HJQILFPVRNHTIG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $55

    Add

    10 mg

    $98

    Add

    25 mg

    $230

    Add

    50 mg

    $376

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    MLR-1023 is an allosteric activator of Lyn kinase (EC50 = 63 nM).1 It has no significant activity against a panel of related kinases. MLR-1023 is orally bioavailable and reduces blood glucose levels in mice subjected to an oral glucose tolerance test.1 This effect is insulin-dependent, with MLR-1023 increasing insulin receptor sensitivity.2 MLR-1023 produces a dose-dependent and durable glucose-lowering effect in chronically treated db/db mice without causing weight gain.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Saporito, M.S., Ochman, A.R., Lipinski, C.A., et al. MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo. J. Pharmacol. Exp. Ther. 342(1), 15-22 (2012).

    2. Ochman, A.R., Lipinski, C.A., Handler, J.A., et al. The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes. J. Pharmacol. Exp. Ther. 342(1), 23-32 (2012).