An SGLT2 inhibitor
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Ertugliflozin

Item No. 21507

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,6-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)-β-L-idopyranose
CAS Number
1210344-57-2
Synonyms
  • PF-04971729
Molecular Formula
C22H25ClO7
Formula Weight
436.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
224, 278 nm
SMILES
CCOC1=CC=C(CC2=CC([C@@]3(O4)OC[C@@]4(CO)[C@@H](O)[C@H](O)[C@H]3O)=CC=C2Cl)C=C1
InChi Code
InChI=1S/C22H25ClO7/c1-2-28-16-6-3-13(4-7-16)9-14-10-15(5-8-17(14)23)22-20(27)18(25)19(26)21(11-24,30-22)12-29-22/h3-8,10,18-20,24-27H,2,9,11-12H2,1H3/t18-,19-,20+,21-,22-/m0/s1
InChi Key
MCIACXAZCBVDEE-CUUWFGFTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $178

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    10 mg

    $312

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    25 mg

    $680

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Ertugliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC50 = 0.927 nM for the human enzyme).1 It is selective for SGLT2 over SGLT1 (IC50 = 2,050 nM for the human enzyme). Ertugliflozin increases urinary glucose excretion in rats in a dose-dependent manner. Formulations containing ertugliflozin have been used in the treatment of type 2 diabetes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mascitti, V., Maurer, T.S., Robinson, R.P., et al. Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors. J. Med. Chem. 54(8), 2952-2960 (2011).