A non-nucleoside reverse transcriptase inhibitor
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Rilpivirine

Item No. 21559

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]-benzonitrile
CAS Number
500287-72-9
Synonyms
  • R278474
  • TMC278
Molecular Formula
C22H18N6
Formula Weight
366.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.3 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMSO: 0.2 mg/ml
λmax
306 nm
SMILES
CC1=CC(/C=C/C#N)=CC(C)=C1NC2=NC(NC3=CC=C(C#N)C=C3)=NC=C2
InChi Code
InChI=1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+
InChi Key
YIBOMRUWOWDFLG-ONEGZZNKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits growth of wild-type HIV with an EC50 value of 0.51 nM.1 It is active against NNRTI-resistant HIV strains with EC50 values less than 1 nM for L100I, K103N, V106A, G190A, and G190S mutants in vitro. Rilpivirine also reduces growth of greater than 80% of 1,500 NNRTI-resistant clinical isolates (EC50s = <10 nM), including strains containing up to eight resistance mutations. In vivo, rilpivirine, when used in combination with cabotegravir, lamivudine (Item No. 18514), and abcavir, reduces the plasma viral titer in HIV-1 infected humanized mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Garvey, L., and Winston, A. Rilpivirine: A novel non-nucleoside reverse transcriptase inhibitor. Expert Opin. Drug Discov. 18(7), 1035-1041 (2009).

    2. Arainga, M., Edagwa, B., Mosley, R.L., et al. A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy. Retrovirology 14(1), 17 (2017).