An HDAC inhibitor
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RGFP109

Item No. 21568

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[6-[(2-aminophenyl)amino]-6-oxohexyl]-4-methyl-benzamide
CAS Number
1215493-56-3
Synonyms
  • RG-2833
Molecular Formula
C20H25N3O2
Formula Weight
339.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH 7.2)(1:6): 0.14mg/mlDMSO: 20 mg/mlEthanol: 1.67 mg/ml
λmax
290 nm
SMILES
NC1=C(NC(CCCCCNC(C2=CC=C(C)C=C2)=O)=O)C=CC=C1
InChi Code
InChI=1S/C20H25N3O2/c1-15-10-12-16(13-11-15)20(25)22-14-6-2-3-9-19(24)23-18-8-5-4-7-17(18)21/h4-5,7-8,10-13H,2-3,6,9,14,21H2,1H3,(H,22,25)(H,23,24)
InChi Key
VOPDXHFYDJAYNS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $120

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    25 mg

    $248

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    50 mg

    $329

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    Product Description

    RGFP109 is a brain-penetrant inhibitor of histone deacetylases (HDACs; IC50s = 60 and 50 nM; Kis = 32 and 5 nM for HDAC1 and HDAC3 in cell-free assays, respectively).1 It has been shown to upregulate frataxin mRNA levels in cultured cells obtained from Friedreich’s ataxia patients and in a GAA repeat-based mouse model of Friedreich’s ataxia.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rai, M., Soragni, E., Chou, C.J., et al. Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich’s ataxia patients and in a mouse model. PLoS One 5(1), e8825 (2010).