A potent inhibitor of SRPK1
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SPHINX31

Item No. 21582

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(4-pyridinyl)-N-[2-[4-(2-pyridinylmethyl)-1-piperazinyl]-5-(trifluoromethyl)phenyl]-2-furancarboxamide
CAS Number
1818389-84-2
Molecular Formula
C27H24F3N5O2
Formula Weight
507.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMF:PBS (pH7.2) (1:30): 0.03 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/ml
λmax
269, 317 nm
SMILES
O=C(C1=CC=C(C2=CC=NC=C2)O1)NC(C=C(C(F)(F)F)C=C3)=C3N(CC4)CCN4CC5=CC=CC=N5
InChi Code
InChI=1S/C27H24F3N5O2/c28-27(29,30)20-4-5-23(35-15-13-34(14-16-35)18-21-3-1-2-10-32-21)22(17-20)33-26(36)25-7-6-24(37-25)19-8-11-31-12-9-19/h1-12,17H,13-16,18H2,(H,33,36)
InChi Key
VURLRACCOCGFDB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $167

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    10 mg

    $274

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    25 mg

    $534

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    Product Description

    SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50 = 5.9 nM).1 It is selective for SRPK1 over a panel of 50 kinases at a concentration of 1 μM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1), an SRPK1 substrate, in PC3 cells (EC50 = 360 nM) and increases expression of the anti-angiogenic VEGF-A165b splice variant in retinal pigment epithelial (RPE) cells. In vivo, SPHINX31 (2 μg per eye) inhibits blood vessel growth and macrophage infiltration in the eyes of a mouse model of choroidal neovascularization.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Batson, J., Toop, H.D., Redondo, C., et al. Development of potent, selective SRPK1 inhibitors as potential topical therapeutics for neovascular eye disease. ACS Chem. Biol. Epub ahead of print, (2017).