A PRMT1 inhibitor
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C-7280948

Item No. 21601

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-N-(2-phenylethyl)-benzenesulfonamide
CAS Number
587850-67-7
Molecular Formula
C14H16N2O2S
Formula Weight
276.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/ml
λmax
265 nm
SMILES
O=S(NCCC1=CC=CC=C1)(C2=CC=C(N)C=C2)=O
InChi Code
InChI=1S/C14H16N2O2S/c15-13-6-8-14(9-7-13)19(17,18)16-11-10-12-4-2-1-3-5-12/h1-9,16H,10-11,15H2
InChi Key
BYWZPUPRVIECEC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $81

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    500 mg

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    1 g

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    Cayman Chemical
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    Product Description

    C-7280948 is a protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 12.8 µM, in vitro).1,2 PRMT1 enzymes transfer a methyl group from S-adenosylmethionine to arginine residues on histones, which leads to transcription.2 PRMT1 is essential for mixed lineage leukemia oncogenic transformation and thus its inhibition is a potential treatment for these aggressive leukemias.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Luo, M. Current chemical biology approaches to interrogate protein methyltransferases. ACS Chem Biol. 7(3), 443-463 (2012).

    2. Heinke, R., Spannhoff, A., Meier, R., et al. Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors. Chem. Med. Chem. 4(1), 69-77 (2009).

    3. Muntean, A.G., and Hess, J.L. The pathogenesis of mixed-lineage leukemia. Annu. Rev. Pathol. 7, 283-301 (2012).