A polypeptide hormone
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Motilin (porcine)

Item No. 21619

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
motilin (swine)
CAS Number
9072-41-7
Molecular Formula
C120H188N34O35S
Formula Weight
2699.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: slightlyPBS (pH 7.2): 5 mg/ml
SMILES
[H]N[C@H](C(N[C@@H](C(C)C)C(N1CCC[C@H]1C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCSC)=O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)CC4=CC=CC=C4
InChi Code
InChI=1S/C120H188N34O35S/c1-9-64(6)97(152-114(184)86-31-22-53-154(86)117(187)96(63(4)5)151-99(169)70(123)56-66-23-12-10-13-24-66)115(185)150-84(57-67-25-14-11-15-26-67)113(183)153-98(65(7)155)116(186)149-83(58-68-32-34-69(156)35-33-68)101(171)135-60-91(161)136-75(39-45-93(163)164)105(175)147-82(55-62(2)3)111(181)145-77(37-43-88(125)158)106(176)140-73(29-20-51-132-119(128)129)103(173)146-80(48-54-190-8)110(180)142-76(36-42-87(124)157)107(177)144-79(41-47-95(167)168)108(178)139-72(28-17-19-50-122)102(172)143-78(40-46-94(165)166)109(179)141-74(30-21-52-133-120(130)131)104(174)148-85(59-90(127)160)112(182)138-71(27-16-18-49-121)100(170)134-61-92(162)137-81(118(188)189)38-44-89(126)159/h10-15,23-26,32-35,62-65,70-86,96-98,155-156H,9,16-22,27-31,36-61,121-123H2,1-8H3,(H2,124,157)(H2,125,158)(H2,126,159)(H2,127,160)(H,134,170)(H,135,171)(H,136,161)(H,137,162)(H,138,182)(H,139,178)(H,140,176)(H,141,179)(H,142,180)(H,143,172)(H,144,177)(H,145,181)(H,146,173)(H,147,175)(H,148,174)(H,149,186)(H,150,185)(H,151,169)(H,152,184)(H,153,183)(H,163,164)(H,165,166)(H,167,168)(H,188,189)(H4,128,129,132)(H4,130,131,133)/t64-,65+,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,96-,97-,98-/m0/s1
InChi Key
LVRVABPNVHYXRT-BQWXUCBYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Motilin is a polypeptide hormone that stimulates gastric motility through release in the small intestine and into the general circulation during fasting.1 In isolated rabbit duodenal segments, porcine motilin (10 nM-1 µM) induced phasic contractions and acetylcholine release from enteric neurons (EC50 = 2.5 nM).2 Formulations containing motilin are used to increase gastrointestinal motility in patients with diabetic gastroparesis, often in combination with erythromycin (Item No. 17191), an antibiotic and agonist at the motilin receptor.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Poitras, P., and Peeters, T.L. Motilin. Curr. Opin. Endocrinol. Diabetes Obes. 15(1), 54-57 (2008).

    2. Kitazawa, T., Ishii, A., and Taniyama, K. The Leu13-motilin (KW-5139)-evoked release of acetylcholine from enteric neurones in the rabbit duodenum. Br. J. Pharmacol. 109(1), 94-99 (1993).