An allosteric activator of AMPK
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ZLN024

Item No. 21644

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[2-(2-bromo-4-methylphenoxy)ethyl]thio]-pyrimidine
CAS Number
723249-01-2
Molecular Formula
C13H13BrN2OS
Formula Weight
325.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 25 mg/mlEthanol: 5 mg/ml
λmax
249, 282 nm
SMILES
CC1=CC(Br)=C(OCCSC2=NC=CC=N2)C=C1
InChi Code
InChI=1S/C13H13BrN2OS/c1-10-3-4-12(11(14)9-10)17-7-8-18-13-15-5-2-6-16-13/h2-6,9H,7-8H2,1H3
InChi Key
KWJRSHZSULRJHE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $106

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    10 mg

    $176

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    25 mg

    $363

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    50 mg

    $655

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    ZLN024 is an allosteric activator of AMP-activated protein kinase (AMPK) heterotrimers (EC50s = 0.42 and 0.95 µM for α1β1γ1 and α2β1γ1, respectively).1 Activation of AMPK by ZLN024 requires phosphorylation of AMPK on Thr172, and ZLN024 protects Thr172 from dephosphorylation by protein phosphatase 2Cα.1 ZLN024 stimulates glucose uptake and fatty acid oxidation in L6 myotubes. In primary hepatocytes, ZLN024 decreases fatty acid synthesis and glucose output.1 ZLN024 reduces liver triacylglycerol and total cholesterol content and improves glucose tolerance in db/db mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, L.-N., Xu, L., Zhou, H.-Y., et al. Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One 8(8), e72092 (2013).