An antiplatelet drug
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Picotamide

Item No. 21690

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-methoxy-N1,N3-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide
CAS Number
32828-81-2
Molecular Formula
C21H20N4O3
Formula Weight
376.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 5 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 0.2 mg/ml
λmax
212 nm
SMILES
O=C(C1=CC=C(OC)C(C(NCC2=CC=CN=C2)=O)=C1)NCC3=CN=CC=C3
InChi Code
InChI=1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27)
InChi Key
KYWCWBXGRWWINE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

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    25 mg

    $263

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    50 mg

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    Product Description

    Picotamide is an antiplatelet drug that inhibits both thromboxane A2 (TXA2) receptors (Kd = 325 nM) and TXA2 synthase.1,2 It significantly inhibits basal and lipopolysaccharide-stimulated TXA2 synthesis by rat peritoneal macrophages when used at 0.5 mM.3 Formulations containing picotamide have potential applications in the reduction of peripheral artery disease in patients with diabetes.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Celestini, A., and Violi, F. A review of picotamide in the reduction of cardiovascular events in diabetic patients. Vasc. Health Risk Manag. 3(1), 93-98 (2008).

    2. Modesti, P.A., Cecioni, I., Colella, A., et al. Binding kinetics and antiplatelet activities of picotamide, a thromboxane A2 receptor antagonist. Br. J. Pharmacol. 112(1), 81-86 (1994).

    3. Matera, G., Chisari, M., Altavilla, D., et al. Selective thromboxane synthetase inhibition by picotamide and effects on endotoxin-induced lethality. Proc. Soc. Exp. Biol. Med. 187(1), 58-61 (1988).