An inhibitor of microtubule polymerization
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N-Deacetylcolchicine

Item No. 21697

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(7S)-7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-benzo[a]heptalen-9(5H)-one
CAS Number
3476-50-4
Synonyms
  • NSC 201400
Molecular Formula
C20H23NO5
Formula Weight
357.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 25mg/mLEthanol: 25mg/mL
λmax
211, 215, 242, 351 nm
SMILES
COC1=C(OC)C(OC)=CC2=C1C(C([C@@H](N)CC2)=C3)=CC=C(OC)C3=O
InChi Code
InChI=1S/C20H23NO5/c1-23-16-8-6-12-13(10-15(16)22)14(21)7-5-11-9-17(24-2)19(25-3)20(26-4)18(11)12/h6,8-10,14H,5,7,21H2,1-4H3/t14-/m0/s1
InChi Key
HFPMXDMZJUJZBX-AWEZNQCLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $219

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    25 mg

    $378

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    Product Description

    N-Deacetylcolchicine is an inhibitor of tubulin polymerization (IC50 = 3 µM for bovine brain tubulin) and a derivative of the microtubule polymerization inhibitor colchicine (Item No. 9000760).1 It stimulates tubulin GTPase activity.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Muzaffar, A., Brossi, A., Lin, C.M., et al. Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids. J. Med. Chem. 33(2), 567-571 (1990).

    2. Lin, C.M., and Hamel, E. Effects of inhibitors of tubulin polymerization on GTP hydrolysis. The Journal of Biological Chemisty 256(17), 9242-9245 (1981).