An active metabolite of mephenytoin
Related Products
Parent Compound(s)
25891(R)-Mephenytoin 11913(S)-Mephenytoin
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Nirvanol

Item No. 21733

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-ethyl-5-phenyl-2,4-imidazolidinedione
CAS Number
631-07-2
Synonyms
  • rac-N-Desmethyl Mephenytoin
  • NSC 150466
  • NSC 33388
  • Phenylethylhydantoin
Molecular Formula
C11H12N2O2
Formula Weight
204.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O=C(N1)C(C2=CC=CC=C2)(CC)NC1=O
InChi Code
InChI=1S/C11H12N2O2/c1-2-11(8-6-4-3-5-7-8)9(14)12-10(15)13-11/h3-7H,2H2,1H3,(H2,12,13,14,15)
InChi Key
UDTWZFJEMMUFLC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $61

    Add

    10 mg

    $96

    Add

    25 mg

    $223

    Add
    Product Description

    Nirvanol is an active metabolite of mephenytoin, a substrate of the cytochrome P450 (CYP) isoform CYP2C19 with anticonvulsant activities.1 It blocks the hind leg tonic extensor phase in a mouse model of seizures induced by maximal electroshock (MES; ED50 = 30 mg/kg).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kupferberg, H.J., and Yonekawa, W. The metabolism of 3-methyl-5-ethyl-5-phenylhydantoin (mephenytoin) to 5-ethyl-5-phenylhydantoin (nirvanol) in mice in relation to anticonvulsant activity. Drug Metab. Dispos. 3(1), 26-29 (1975).