A nootropic and neuroprotective agent
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Leteprinim (potassium salt)

Item No. 21748

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]-benzoic acid, monopotassium salt
CAS Number
192564-13-9
Synonyms
  • AIT 082
Molecular Formula
C15H12N5O4 • K
Formula Weight
365.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
265 nm
SMILES
O=C1C2=C(N(CCC(NC3=CC=C(C([O-])=O)C=C3)=O)C=N2)NC=N1.[K+]
InChi Code
InChI=1S/C15H13N5O4.K/c21-11(19-10-3-1-9(2-4-10)15(23)24)5-6-20-8-18-12-13(20)16-7-17-14(12)22;/h1-4,7-8H,5-6H2,(H,19,21)(H,23,24)(H,16,17,22);/q;+1/p-1
InChi Key
MICLTPPSCUXHJT-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $46

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    5 mg

    $179

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    10 mg

    $290

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    Product Description

    Leteprinim is a nootropic and neuroprotective agent and a derivative of hypoxanthine (Item No. 22254).1,2,3 Leteprinim (10 and 100 µM) enhances nerve growth factor induced neurite growth in PC12 cells and increases the production of synaptophysin when used at concentrations ranging from 5 to 100 ng/ml.1,3 It enhances working memory in a win-shift T-maze test in young mice and reduces time delay-induced working memory errors in old mice with mild or moderate, but not severe, age-induced memory deficits when administered at a dose of 30 mg/kg.4 In a rat model of spinal crush injury, leteprinim (60 mg/kg per day for 21 days) reduces impairments in locomotor function and reduces increases in the amount of necrotic tissue and the number of reactive astrocytes in the spinal cord.2 It reduces hypoxia-induced decreases in neuronal density in the hippocampal CA1, CA3, and dentate gyrus regions and decreases the number of caspase-3 and TUNEL-positive cells in the hippocampus and prefrontal and parietal cortices in neonatal rats when administered at a dose of 60 mg/kg.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Middlemiss, P.J., Glasky, A.J., Rathbone, M.P., et al. AIT-082, a unique purine derivative, enhances nerve growth factor mediated neurite outgrowth from PC12 cells. Neurosci. Lett. 199(2), 131-134 (1995).

    2. Jiang, S., Khan, M.I., Middlemiss, P.J., et al. AIT-082 and methylprednisolone singly, but not in combination, enhance functional and histological improvement after acute spinal cord injury in rats. Int. J. Immunopathol. Pharmacol. 17(3), 353-366 (2004).

    3. Lahiri, D.K., Ge, Y.-W., and Farlow, M.R. Effect of a memory-enhancing drug, AIT-082, on the level of synaptophysin. Ann. N. Y. Acad. Sci. 903(1), 387-393 (2000).

    4. Glasky, A.J., Melchior, C.L., Pirzadeh, B., et al. Effect of AIT-082, a purine analog, on working memory in normal and aged mice. Pharmacol. Biochem. Behav. 47(2), 325-329 (1994).

    5. Gencpinar, P., Tüzün, F., Ozbal, S., et al. Effects of neotrofin on neonatal hypoxic ischemic brain injury. Neurosci. Lett. 505(2), 205-210 (2011).