An endogenous purine derivative
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Labeled Version(s)
36330Hypoxanthine-d4
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Hypoxanthine

Item No. 22254

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,9-dihydro-6H-purin-6-one
CAS Number
68-94-0
Synonyms
  • 6-Hydroxypurine
  • NSC 14665
  • NSC 129419
Molecular Formula
C5H4N4O
Formula Weight
136.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mLDMSO: 30 mg/mLDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mLEthanol: 0.5 mg/mL
λmax
251 nm
SMILES
O=C1NC=NC2=C1NC=N2
InChi Code
InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
InChi Key
FDGQSTZJBFJUBT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $36

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    10 g

    $53

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    25 g

    $77

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    Product Description

    Hypoxanthine is an endogenous purine derivative and the major purine involved in the purine salvage pathway in the brain.1 Intrastriatal administration of hypoxanthine (10 µM) increases mitochondrial complex II, also known as succinate dehydrogenase, activity and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rats. Hypoxanthine also induces hyperuricemia in mice.2 Spinal fluid levels of hypoxanthine are increased in patients with Lesh-Nyhan syndrome, an inborn error of metabolism characterized by cognitive deficits, motor dysfunction, self-mutilation, and hyperuricemia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Biasibetti-Brendler, H., Schmitz, F., Pierozan, P., et al. Hypoxanthine induces neuroenergetic impairment and cell death in striatum of young adult Wistar rats. Mol. Neurobiol. 55(5), 4098-4106 (2018).

    2. Yong, T., Zhang, M., Chen, D., et al. Actions of water extract from Cordyceps militaris in hyperuricemic mice induced by potassium oxonate combined with hypoxanthine. J. Ethnopharmacol. 194, 403-411 (2016).