An inhibitor of IGF-1R
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AGL 2263

Item No. 21776

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
αE-[(2,3-dihydro-2-oxo-5-benzoxazolyl)methylene]-3,4-dihydroxy-β-oxo-benzenepropanenitrile
CAS Number
638213-98-6
Molecular Formula
C17H10N2O5
Formula Weight
322.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 2 mg/ml
λmax
213, 222, 252, 350 nm
SMILES
OC1=CC=C(C(/C(C#N)=C/C2=CC=C(OC(N3[H])=O)C3=C2)=O)C=C1O
InChi Code
InChI=1S/C17H10N2O5/c18-8-11(16(22)10-2-3-13(20)14(21)7-10)5-9-1-4-15-12(6-9)19-17(23)24-15/h1-7,20-21H,(H,19,23)/b11-5+
InChi Key
IUGRBTCJEYEDIY-VZUCSPMQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $75

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    5 mg

    $333

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    10 mg

    $589

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    Product Description

    AGL 2263 is an inhibitor of the insulin-like growth factor 1 receptor (IGF-1R; IC50 = 0.43 μM).1 It also inhibits the insulin receptor (IR), protein kinase B (PKB), and Src in a cell-free assay (IC50s = 0.4, 55, and 2.2 μM, respectively). AGL 2263 inhibits IGF-1R autophosphorylation and phosphorylation of the downstream elements IRS-1, PKB, and ERK2 in an ATP-independent manner. It inhibits colony formation of PC3 and LNCaP prostate and MCF-7 and MDA-MB-468 breast cancer cells in soft agar (IC50s = 4.3, 9, 17, and 6 μM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Blum, G., Gazit, A., and Levitzki, A. Development of new insulin-like growth factor-1 receptor kinase inhibitors using catechol mimics. The Journal of Biological Chemisty 278(42), 40442-40454 (2003).