A selective antagonist of RARγ
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MM-11253

Item No. 21800

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylic acid
CAS Number
345952-44-5
Molecular Formula
C28H30O2S2
Formula Weight
462.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/ml
SMILES
CC(CCC1(C)C)(C)C2=C1C=C(C3(SCCS3)C4=CC(C=CC(C(O)=O)=C5)=C5C=C4)C=C2
InChi Code
InChI=1S/C28H30O2S2/c1-26(2)11-12-27(3,4)24-17-22(9-10-23(24)26)28(31-13-14-32-28)21-8-7-18-15-20(25(29)30)6-5-19(18)16-21/h5-10,15-17H,11-14H2,1-4H3,(H,29,30)
InChi Key
DPVGXUNWCVEIGT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    MM-11253 is a synthetic, conformationally restricted retinoid that acts as a selective antagonist of retinoic acid receptor γ (RARγ).1 It dose-dependently blocks the ability of RARγ-selective agonists, but not retinoic acid (all-trans retinoic acid; Item No. 11017), to inhibit the growth of oral squamous cell carcinoma cells in vitro.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Le, Q.T., Dawson, M.I., Soprano, D.R., et al. Modulation of retinoic acid receptor function alters the growth inhibitory response of oral SCC cells to retinoids. Oncogene 19(11), 1457-1465 (2000).